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What are sirtuins?

Sirtuins, or Sirt2 proteins, are a class of proteins with enzymatic activity; they act as histone deacetylases or mono-ribosyltransferases. Sirtuins regulate important metabolic pathways in both prokaryotes and eukaryotes. Their name derives from a yeast silencing regulatory gene involved in the control of cellular development. Sirtuins mediate phenomena such as aging, transcription regulation, apoptosis, and stress resistance, and they also influence energy efficiency and alertness during periods of low caloric intake (caloric restriction).

SIRT500 Plus is a dietary supplement containing extracts from certain plants rich in SIRT-activating substances (called STACs). It is designed to provide daily doses of selected SIRT activators, stimulating continuous cellular renewal as occurs naturally in a young organism.

The composition of SIRT500 Plus is intended to replace the daily intake of fruit and vegetables containing STACs at levels sufficient to promote cellular renewal — quantities that would otherwise be very difficult to consume in an ordinary diet. For example, to achieve the significant amount of a substance able to stimulate the production of SIRT1 and SIRT2, one would need to consume 5–6 kilograms of blueberries and 5 liters of fresh pomegranate juice every day.

SIRT500 Plus is formulated to ensure a constant presence of SIRT activator molecules in the human body with slow absorption, providing prolonged anti-aging and immune defense effects throughout the day.

SIRT500 Plus contains natural extracts that, in synergy, help stimulate the production of all sirtuins (SIRT1–7), increasing their presence in the body by 3 to 14 times. It also contains Polydatin (a stilbenoid glucoside derived from Resveratrol), whose effectiveness is documented in many scientific studies.

The formula of SIRT500 Plus specifically aims to stimulate the continuous renewal of healthy cells in the nervous system, skin, bone tissue, muscles, and internal organs. Maintaining high sirtuin levels promotes a responsive and efficient immune system. Moreover, SIRT500 Plus provides vitamins, antioxidants, and other elements that support the effective absorption of these substances in the human digestive tract.

Many anti-aging products available today are focused on cosmetic or aesthetic treatments. SIRT500 Plus, on the other hand, is a dietary supplement developed on the basis of world-class scientific research, and it works systemically throughout the body.

SIRT500 Plus activates the natural production of sirtuins (Sirt 1–7) and works at the cellular level, providing the substances that support the healthy replication of tissue cells. It operates gradually, in line with the natural schedule of cellular replacement.

The formulation provides ingredients that help activate metabolism and support cellular rejuvenation, contributing to the elimination of toxins and harmful residues accumulated in cells, which are also responsible for premature aging. It promotes cellular “reprogramming,” fostering longevity and protection against age-related diseases.

SIRT500 Plus has no contraindications except for individuals allergic to its active ingredients. In such cases, or for those suffering from chronic or serious diseases such as cancer or hemophilia, it is recommended to consult a doctor before taking SIRT500 Plus regularly.

Two tablets per day: one in the morning and one in the evening.

SIRT500 Plus is designed to strengthen the immune system and protect the body from age-related diseases. It provides certain plant-based extracts that would otherwise be very difficult to consume in sufficient amounts through a normal diet. However, SIRT500 Plus is a dietary supplement, not a medicine. In case of illness, you should always consult a doctor.

The natural production of sirtuins begins to decrease after the age of 30-35. Therefore, it is advisable to start supplementing your diet with SIRT500 Plus around this age.

According to clinical tests, prolonged and continuous use of SIRT500 Plus stimulates the natural production of sirtuins, which can help counteract the effects of aging.

The perception of changes from consistent and prolonged use of SIRT500 Plus is entirely individual. In elderly individuals, effects are often noticeable within the first week of use, while in younger healthy individuals, the first benefits usually appear within 4 to 8 weeks.

The first benefits observed include:

  • improved sleep;
  • increased resistance to psycho-physical stress;
  • greater physical and mental energy.

SIRT500 Plus can be taken either on a full or empty stomach.

SIRT500 Plus can be taken either on a full or empty stomach.