OUR MISSION:
Increase healthy lifespan
Uniqueness, Excellence, Avant-garde. SirtLife, brings supplements to the next level
SIRTLIFE annually funds many scientific research on Sirtuins and their role in human biological processes
Reactive Oxygen Species production
A murine cell line was used and treated with a pro-oxidant molecule (6 hydroxydopamine, 6ohda) for 3 hrs, in association with the co-treatment of cells with both 6ohda and SIRT500.
Results highlighted a significant increase in Reactive Oxygen Species (ROS) production was observed following 6ohda administration. Conversely, the cotreatment with SIRT500 blunted ROS levels following the pro-oxidant stimulus, suggesting the compound has a relevant antioxidant activity.
Effects on cellular senescence
The effects of SIRT500 on cellular senescence was tested using the same neuroblastoma cell line utilized to test ROS levels, thus cells were pre-treated with A5 for 24 hours (in agreement with the previously observed time-dependent SIRT1 activation), and subsequently doxorubicin 0.5 μM was added for 3 hrs.
Results highlighted that doxorubicin significantly increased p21 levels, a well-known biomarkers for senescence. The pre-treatment with SIRT500 reduced p21 levels, blunting the senescent phenotype, according to SIRT1 activation mediated by its activators contained in SIRT500 compound.
Protective role against neurodegenerative disorders
SIRT500’s ability to induce neuronal differentiation according to its protective effect against oxidative stress and cellular senescence was evaluated by treating neuroblastoma cell line with SIRT500 or with DMSO 1,25% as control for differentiation.
Results highlighted SIRT500 was able to induce neuronal differentiation represented by the formation of long filaments that were totally absent in control undifferentiated cells. Thus, these preliminary results suggest a potential protective role against neurodegenerative disorders.
Role of Exercise and Natural Protective Substances on Sirtuin Activation
The advancement of chronological age is characterized by the progression of symptoms of chronic degenerative diseases that are triggered or accelerated in their progression by unhealthy lifestyles, decreased fitness, inadequate nutrition with decreased consumption of natural protective substances.
Recent scientific evidence indicates that it could be possible to prevent, or at least delay age-related chronic diseases to extend the period of healthy longevity, by strategies that could minimize the duration of the decline phase.
Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment
Stroke is now the second leading cause of death worldwide and is defined as an impairment in blood supply to the brain and is linked to different cardiovascular dysfunctions.
Increased levels of reactive oxygen species, which contribute to enhance oxidative stress, have been reported during ischemic stroke.
Data
Scientific research
SIRTLIFE products are the result of years of research and studies on the benefits of Sirtuins. Thanks to an international and interdisciplinary team, the SIRTLIFE line is created and in continuous improving, exclusive, cutting-edge and multi-certified products. SIRTLIFE products contain natural extracts SIRT-Activators which play a fundamental role in multiple biological processes capable, among other things, of slowing down aging.
Press coverage
Dalla Vitamina D alla melatonina ecco i nostri alleati contro il Covid
Emergenza insonnia post – lockdown “Luce e vita sociale aiutano a dormire
Insonnia, la pandemia ci ha rubato il son-no: ecco quali sono i rimedi “soft” per dormire bene
L’ultima ora legale, Istruzioni per l’uso
Longevità: come attivare le proteine sirtuine per vivere meglio e più a lungo
“Geni della longevità”: grazie a un mix di polifenoli si attivano e hanno un’azione an-tiossidante e antiaggregante. Ecco come.
About us
The Company
Originality, uniqueness, excellence, avant-garde: our core values. Sirtlife is born, the exclusive brand that takes supplements to a higher level. Our product lines are always born from the studies of international top-level scientists, passing a rigorous process of internal certification and in collaboration with international Universities. The health and experience of our customers is our priority, the excellence of Sirtlife: a luxury for the few, today accessible to all.